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Vol.38 No.2 contents | Japanese/English |
- Original Article -
Histopathological and Immunohistochemical Analysis of 6 Cases of Solitary Fibrous Tumor of the Pleura
Futoshi Tsubokawa1,2, Yukio Takeshima1, Taijirou Sueda2, Hiroo Shikata2, Shinkichiro Yoshioka3 and Kouki Inai1Second Department of Pathology1, First Department of Surgery2, Second Department of Surgery3, Hiroshima University School of Medicine.
We examined histopathological features as well as immunohistochemical features of 6 cases of solitary fibrous tumor of the pleura. Three of six patients were men and the others were women. The ages ranged from 49 to 67 and the mean was 58 years old. The resected tumors measured 1.5∼20 cm (mean: 8.3 cm) in the greatest dimension, and 4 cases were attached to the visceral pleura by a pedicle and 2 cases were located in the parietal pleura. Grossly, the tumor was encapsulated and the cut surface was firm, gray-white in color. Microscopically, spindle cells were arranged haphazardly in accordance with a "patternless pattern" . Immunohistochemically spindle cells expressed CD34 and vimentin, and on the contrary, keratin was negative. In each of the cases, some tumor cells expressed neurofilament, S-100 or α-SMA, which indicated differentiation to neural cell, nerve sheath cell or smooth muscle cells, and in addition, bcl-2 was strongly expressed in all cases.
key words: Solitary fibrous tumor, CD34, bcl-2
Received: January 5, 1998
Accepted: February 2, 1998
JJLC 38 (2): 117-122, 1998
