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Vol.38 No.3 contents | Japanese/English |
- Case Report -
A Case of Platelet Derived Growth Factor Producing Lung Adenocarcinoma with Osteoplastic Metastasis
Hitoshi Haneda and Makoto KoizumiDepartment of Respiratory Medicine, Sapporo City General Hospital
A 65-year-old woman visited our hospital to investigate a headache and abnormal chest shadow. She had lung adenocarcinoma in the right upper lung, and multiple bone and lung metastasis. Skull frontal bone biopsy confirmed the diagnosis of the metastasis of lung adenocarcinoma. Immunohistochemical staining showed positive findings for platelet derived growth factor, but negative finding for TGFβ. PDGFs are potent bone cell mitogens and promote metastatic cell growth in target organ. PDGF may also be related to osteoplastic metastasis of lung adenocarcinoma.
key words: Osteoplastic metastasis, Lung cancer, PDGF
Received: March 16, 1998
Accepted: May 14, 1998
JJLC 38 (3): 249-253, 1998
