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Vol.38 No.6 contents | Japanese/English |
- Original Article -
Immunohistochemical Study of Thymic Tumors
Hiroiku Hara, Shigeki Sugiyama and Takuro MisakiFirst Department of Surgery, Toyama Medical & Pharmaceutical University
In this study we immunohistochemically stained 23 formalin-fixed thymic tumors (21 thymomas, one carcinoma and one carcinoid ) resected in our institutes over the past 14 years, with various antibodies to proteins (p53 protein, PCNA,EMA, CEA, NSE, cytokeratin, TGF-beta 1) which werer related to growth of tumors. Positive staining was seen in 35% for p53 protein, 48% for EMA, 17% for CEA, 17% for NSE, 96% for cytokeratin, 0% for TGF-beta 1, respectively. The number of cells staining for PCNA was 478±197 per 1,000 cells. The positivity for p53 protein, PCNA and EMA was higher in more advanced cases. In particular, the EMA positive group had a significantly worse outcome than the negative group. Though positivity of NSE was low, all NSE positive cases were advanced.
key words: Thymic tumor, Immunohistochemical study, p53, EMA, NSE
Received: June 2, 1998
Accepted: September 7, 1998
JJLC 38 (6): 681-690, 1998
