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Vol.39 No.3 contents | Japanese/English |
- Case Report -
A Case of Large Cell Neuroendocrine Carcinoma Developing in an Emphysematous Bulla
Kazuhiro Sakamoto1,3, Satoshi Hirokawa1, Yasunobu Yamazaki1, Takashi Suda1, Ken Ide1 and Hiroshi Yonamine2Department of Surgery1, Department of Internal Medicine2, Saiseikai Yokohamashi Nanbu Hospital, Department of Respiratory Surgery, Yokohama Rosai Hospital3
A 50-year-old man was admitted to our hospital with an abnormal shadow on chest X-ray. Chest CT scan showed a 2.4×1.5 cm tumor adjacent to a bulla in the right upper lobe. Transbronchial lung biopsy failed to obtain a definitive diagnosis. We performed tumorectomy. The tumor was located in the lateral wall of the bulla and lung cancer was diagnosed. Right upper lobectomy with mediastinal lymph node dissection (R2a) was then performed. Histologically, the tumor cells were medium to large in size, and had a trabecular growth pattern. Mitoses were frequently observed and focal necroses were also seen in the tumor. Because the immunohistochemical staining of the tumor was positive for synaptophysin and Leu-7, the tumor was pathologically diagnosed as large cell neuroendocrine carcinoma (LCNEC).
key words: Lung cancer, Large cell neuroendocrine carcinoma, Emphysematous bullae
Received: April 6, 1999
Accepted: April 28, 1999
JJLC 39 (3): 345-350, 1999
