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Vol.39 No.4 contents | Japanese/English |
- Case Report -
Percutaneous Intratumoral Injection of Anti-cancer Agent to the Patients with Functionally Inoperable Lung Tumor
Chikabumi Kadoyama, Makoto Suzuki, Mizuto Otsuji and Teruaki MizobuchiDepartment of Respiratory Surgery, Omiya Red Cross Hospital
We performed percutaneous intratumoral injection (PCTI) of an anti-cancer drug (mitomycin-C) into the lung tumors of two patients who previously had lung surgery for malignant tumors and in whom further resection was contraindicated becau se of poor cardiopulmonary function. Case 1: A 76-year-old man with pulmonary emphysema underwent right lower lobe lobectomy for primary lung cancer. Three years later, a malignant tumor was found in the periphery of the ipsilateral upper lobe. Partial resection of this tumor was incomplete due to firm adhesion and a severely emphysematous lung. We performed PCTI with mitomycin-C (2 mg in 5 ml saline) under TV fluoroscopy twice at an interval of one week. The tumor disappeared radiographically and his quality of life had been unchanged until his readmission due to worsing of pulmonary emphysema 35 months after the injections. Case 2: A 70-year-old man, who had had operations for colon cancer and metastases to the liver and lung, was admitted because of a new metastasis in the periphery of the ipsilateral lung (lt-S9). We chose PCTI, performed in the same manner as in case 1, due to his history of myocardial infarction and sublethal ventricular tachycardia which was encountered on his first lung operation. So far, we have done PCTI twelve times in our outpatient service in this and other cases of new metastases. The first tumor changed to a scar radiographically and his performance status has been unchanged for three years after the first PCTI. Although there may be room for further improvement in this method, PCTI using anti-cancer agents might be one effective local therapy for patients with peripheral lung cancer that is unresectable because of poor cardiopulmonary function.
key words: Percutaneous intratumoral injection, Lung tumor, Anti-cancer drug, Mitomycin-C
Received: April 21, 1999
Accepted: June 7, 1999
JJLC 39 (4): 465-470, 1999
