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Vol.39 No.4 contents | Japanese/English |
- Case Report -
A Resected Case of Pulmonary Adenocarcinoma with Multiple Atypical Adenomatous Hyperplasia
Takahiko Misao1, Katashi Satoh1,2, Takuya Kobayashi1,2 and Junji Morita31Department of Respiratory Disease, Kagawa Prefectural Cancer Detection Center, 2Department of Radiology, Kagawa Medical School, 3Department of Chest Surgery, Takamatsu Red-cross Hospital
Background: Atypical adenomatous hyperplasia (AAH) is an epithelial proliferative lesion, which has been considered to suggest a precancerous state of pulmonary adenocarcinoma. AAH is often observed especially in concomitance with well differentiated papillary adenocarcinoma. Case: A 58-year-old man visited our hospital with an abnormal shadow on chest X-ray. Chest CT showed a 3-cm tumor shadow with two small nodules which were adjacent to the main tumor in the middle lobe, and a 1-cm small nodule in the right S3. Both transbronchial biopsy in the middle lobe and CT-guided percutaneous lung biopsy of S3 revealed adenocarcinomas. Right upper and middle lobectomy with regional lymph node dissection (R2) was performed. Histological examination disclosed that the tumor in the middle lobe was well differentiated adenocarcinoma (p-T2N0M0) and the other three small nodules were atypical adenomatous hyperplasia. Conclusion: We experienced a case of pulmonary adenocarcinoma with multiple AAH. It may be difficult to differentiate AAH from primary adenocarcinoma or intrapulmonary metastasis, when small nodular lesions coexist with adenocarcinoma of the lung.
key words: Lung cancer, Adenocarcinoma, Atypical adenomatous hyperplasia
Received: April 13, 1999
Accepted: July 1, 1999
JJLC 39 (4): 471-476, 1999
