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Vol.40 No.1 contents | Japanese/English |
 | Full Text of PDF (56K) Article in Japanese |
- Original Article -
Hiccup Observed during Chemotherapy for Lung Cancer
Kazuhiko Shibata, Kazuo Kasahara* and Masaki Fujimura*Division of Respiratory Medicine, Koseiren Takaoka Hospital, *Department of Internal Medicine (III), Kanazawa University School of Medicine
Objective: To ascertain the clinical impression that hiccups are frequently observed during cisplatin (CDDP) -based chemotherapy for lung cancer, and to clarify onset, duration and therapeutic intervention of this troublesome symptom. Methods: Thirteen patients who received systemic chemotherapy for lung cancer from April 1997 to May 1998 were included in this retrospective analysis. The information about ocurrence of hiccup was obtained from medical and nursing records. Results: Nine patients received CDDP-based chemotherapy. They simultaneously received prophylactic antiemetic therapy with a 5-HT3 receptor antagonist and dexamethasone. Hiccups were observed in 8 of 9 patients and in 11 courses among a total of 24 courses. Hiccups began at 18 to 42 hours (median 26 hours) after starting CDDP infusion, and lasted for 1 to 37 hours (median 11 hours). None of the four patients who received only non-CDDP based therapy experienced hiccups. Conclusion: Hiccups were frequently observed during CDDP-based chemotherapy for lung cancer.
key words: hiccup, 5-HT3 receptor antagonist, antiemetic therapy, cisplatin, dexamethasone
Received: August 19, 1999
Accepted: December 20, 1999
JJLC 40 (1): 33-37, 2000
