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Vol.40 No.3 contents | Japanese/English |
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- Case Report -
A Case of Irinotecan-Induced Pneumonitis
Ken-ichiro Inoue, Noriya Hiraoka, Yoshihiro Kasamatsu, Yutaka Kawahito, Keiji Yoshioka, and Sadayoshi YokooFirst Department of Internal Medicine, Matsushita Memorial Hospital, Osaka, Japan.
We report a case of pneumonitis caused by irinotecan (CPT-11). A 55-year-old man was admitted for further evaluation and treatment of small cell lung cancer (SCLC). After irradiation for a focal brain metastatic lesion, irinotecan was administered intravenously. Three weeks after the chemotherapy, he had a high fever with diffuse patchy attenuation on a chest computed tomography (CT) scan. A significant increase in the number of mast cells in his bronchoalveolar lavage (BAL) fluid was also found. The pneumonitis was subsequently controlled by steroid therapy, with a decrease in the number of mast cells in the BAL fluid.
key words: Irinotecan, Small cell lung cancer, Pneumonitis, Bronchoalveolar lavage, Mast cell
Received: November 29, 1999
Accepted: March 8, 2000
JJLC 40 (3): 219-221, 2000
