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Vol.40 No.7 contents | Japanese/English |
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- Original Article -
Clinical Features of Primary Lung Cancer in Cases with Previous Lung Diseases
Koichi Yamazaki, Yoshihiro Okamoto, Toshiyuki Harada, Osamu Wakabayashi, Satoshi Oizumi, Akira Kamimura, Hirokazu Ojima, Shigeaki Ogura, Hirotoshi Akita and Yoshikazu KawakamiFirst Department of Medicine, Hokkaido University School of Medicine, Sapporo 060-8638, Japan
Objective: We studied clinical features of primary lung cancer in cases with previous lung diseases. Study Design: A total of 755 patients with primary lung cancer who were admitted to our hospital from January, 1983 to December, 1998 were investigated retrospectively. Results: Lung tuberculosis was the most frequently found previous lung disease in primary lung cancer (16.6%), followed by emphysema (10.7%), interstitial pneumonitis (4.0%), bronchial asthma (1.9%) and pneumoconiosis (1.4%). Cases with primary lung cancer and emphysema increased during this period, whereas respiratory function, including FEV1.0%, did not show significant differences. The frequency of males was significantly higher for cases with emphysema, interstitial pneumonitis or lung tuberculosis than that of females (P<0.01). The average age at onset and the smoking index were significantly higher for patients with emphysema or lung tuberculosis than for those without (P<0.01). Squamous cell carcinoma occurred more frequently in cases with emphysema, interstitial pneumonitis or pnemoconiosis than other histologic types, while adenocarcinoma occurred more in cases with bronchial asthma than with other histologic types, although the differences were not significant except for emphysema (P<0.01). In addition, the frequency of advanced stages (Stages III and IV) was significantly higher for those with interstitial pneumonitis than that of less advanced stages (P=0.015). Conclusion: Primary lung cancer following different previous lung diseases has its own clinical features and it would be useful to understand these characteristics to clarify the etiology of primary lung cancer.
key words: Primary lung cancer, Previous lung diseases, Lung tuberculosis, Emphysema, Interstitial pneumonitis
Received: April 7, 2000
Accepted: August 17, 2000
JJLC 40 (7): 731-736, 2000
