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Vol.41 No.1 contents | Japanese/English |
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- Original Article -
Is DNA Ploidy Pattern a Prognostic Factor for Postoperative Adjuvant Chemotherapy for Non-small Cell Lung Cancer?
Tatsuya Yamamoto1,2, Masafumi Kawamura1, Koichi Kobayashi1 and Tsuneo Ishihara1,31Department of Surgery, Keio University School of Medicine, 2Department of Surgery, KKR Tachikawa Hospital, 3International Catholic Hospital
Objective: We retrospectively reviewed the relationship between DNA ploidy and postoperative chemotherapy in 128 patients with non-small cell lung cancer (NSCLC). Methods: Patients with NSCLC who underwent curative operation were divided into four groups as follows. StageI patients were divided randomly into group A (1 course of CDDP+VDS and 5-FU p.o. for 2 years) and group B (without chemotherapy). Patients with stage II and IIIA were divided randomly into group C (2 courses of CDDP+VDS and 5-FU p.o. for 2 years) and group D (2 years of only 5-FU p.o.). DNA patterns were examined in each patient. Results: The five-year survival rates of the patients with DNA diploidy were 81.2% in group A, 100% in group B, 25.0% in group C and 58.3% in group D, respectively. The five-year survival rates of the patients with DNA aneuploidy were 83.5% in group A, 78.9% in group B, 32.7% in group C and 8.3% in group D, respectively. In stageI patients with DNA diploidy, the postoperative survival rate was significantly worse in group A (CDDP+VDS and 5-FU p.o.) than in group B (without chemotherapy) (p=0.03). On the other hand, in stage II and IIIA patients with DNA aneuploidy, the postoperative survival rate was better in group C (CDDP+VDS and 5-FU p.o.) than in group D (5-FU p.o. only) (p=0.07). Conclusion: It may be useful to enhance the effectiveness of adjuvant chemotherapy to stratify NSCLC patients according to DNA ploidy pattern.
key words: Non-small cell lung cancer, DNA ploidy pattern, Postoperative adjuvant chemotherapy
Received: July 7, 2000
Accepted: November 16, 2000
JJLC 41 (1): 3-9, 2001
