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Vol.41 No.7 contents | Japanese/English |
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- Original Article -
Dose Finding Study of Carboplatin and Weekly Paclitaxel for Advanced Non-small Cell Lung Cancer
Kansai Clinical Oncology Group（KCOG) , Thoracic Malignancy Study Group, Masataka Hirabayashi1, Masato Okuda1, Kazuo Endoh1, Masayoshi Teramachi1, Kazuyuki Yamaguchi2, Masahiro Moriyama3, Yusuke Watanabe4 and Masaharu Nakade41Department of Respiratory Diseases, Hyogo Prefectural Tsukaguchi Hospital, 2First Department of Internal Medicine, Kansai Medical University, 3Department of Radiology, Shimane Medical University, 4Department of Respiratory Surgery, Osaka Red Cross Hospital
Purpose: This study aimed to determine the maximum tolerated doses of paclitaxel administered weekly in combination with a fixed dose of carboplatin, and to assess the toxicity and preliminary activity of this combination in patients with previously untreated, advanced non-small cell lung cancer. Patients and Methods: Fifteen patients (10 men and 5 women) were enrolled. The median age was 67 years (range 46 to 76 years). Carboplatin was administered on day 1 (area under the curve = 6 mg/ml· min), and paclitaxel was administered on days 1, 8, and 15. The starting dose of paclitaxel was 50 mg/m2, which was increased in 10 mg increments. Chemotherapy was repeated every 4 weeks. Results: Two of the three level 4 patients (paclitaxel 80 mg/m2) experienced dose-limiting toxicities: one patient experienced neutropenic fever with grade 3 diarrhea; the other experienced grade 3 lethargy with grade 3 diarrhea and grade 3 hyponatremia, and the performance status of this patient gradually deteriorated. Thus, 80 mg/m2 was defined as the maximum tolerated dose in this schedule. The objective response rate was 46.7% (7/15). Conclusion: The dose level of paclitaxel 70 mg/m2 on days 1, 8, and 15 in combination with carboplatin AUC=6 on day1 of a four week cycle was recommended for a phase II study.
key words: Non-small cell lung cancer, Chemotherapy, Weekly paclitaxel
Received: September 3, 2001
Accepted: November 5, 2001
JJLC 41 (7): 767-772, 2001
