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Vol.42 No.3 contents | Japanese/English |
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- Case Report -
TTF-1 Immunostaining in the Diagnosis of Gastric Metastasis From Lung Adenocarcinoma
Takeshi Suzuki1, Toyoaki Hida1, Yoshitsugu Horio1, Motoichi Suyama2, Yasushi Yatabe3, Takahiko Sugiura11Department of Respiratory Medicine, 2Department of Thoracic Surgery and 3Department of Anatomic and Molecular Diagnostic Pathology, Aichi Cancer Center, Japan
Background. Although gastric metastases from lung cancer are considered to be uncommon, the distinction of a primary gastric carcinoma from a metastatic lesion of lung cancer is often difficult because of overlapping pathologic features. Recently the antibody to thyroid transcription factor-1 (TTF-1) has been shown to be a fairly specific marker for lung cancer. We report two cases of gastric metastasis from lung adenocarcinoma with positive immunostaning with TTF-1. Case. Case 1 was a 56-year-old woman who was referred to our hospital with an abnormal shadow on a chest X-ray film. The tumor was diagnosed as adenocarcinoma (cT1N0M0 stage IA) . Nine months after curative resection, she developed epigastralgia, and gastrointestinal endoscopy was performed. Case 2 was a 52-year-old man referred to our hospital with malignant pleural effusion. The clinical stage was IIIB (cT4N2M0) . After a second systemic course of chemotherapy with carboplatin and paclitaxel, he complained of epigastric discomfort. Gastrointestinal endoscopy was performed. The histological specimens of both cases were immunostained with a monoclonal antibody to TTF-1. Conclusion. Two cases of lung adenocarcinoma with metastasis to the stomach are reported, in each of which immunostaning for TTF-1 was useful in obtaining an accurate diagnosis.
key words: Lung cancer, Gastric metastasis, Thyroid transcription factor-1
Received: January 28, 2002
Accepted: March 28, 2002
JJLC 42 (3): 221-225, 2002
