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Vol.43 No.2 contents | Japanese/English |
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- Case Report -
A Case of Undifferentiated Thymic Carcinoma
Katsutoshi Adachi1,2, Motoshi Takao3, Isao Yada3, Naoki Hosaka4Department of 1Thoracic and Cardiovascular Surgery, 4Pathology, Toyooka Hospital, Japan, 2Department of Thoracic and Cardiovascular Surgery, Shingu Medical Center, Japan, 3Department of Thoracic and Cardiovascular Surgery, Mie University, Japan
Background. We report a case of undifferentiated thymic carcinoma that invaded the pericardium and the upper lobe of the right lung. Case. A 61-year-old woman was admitted to our hospital presenting with constriction of the chest and back pain. A CT scan showed an anterior mediastinal tumor and the patient was operated on under a diagnosis of non-invasive thymoma. The tumor was located in the right lobe of the thymus. Since the tumor invaded the pericardium and the upper lobe of the right lung, resection of adjacent structures was necessary. Postoperative pathological examination indicated undifferentiated thymic carcinoma. Protein immunostaining using bcl-2 was positive while p53 protein and ki-67 protein immunostaining were 82% and 38% positive, respectively. The patient was treated postoperatively by adjuvant chemotherapy, mainly with CDDP. Conclusions. Three years and ten months after surgery the patient is well and is free from any signs of recurrence.
key words: Thymic carcinoma, Undifferentiated carcinoma, p53, bcl-2 , ki-67
Received: October 2, 2002
Accepted: January 22, 2003
JJLC 43 (2): 149-152, 2003
