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Vol.43 No.6 contents

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- Case Report -

A Case of Amylase-producing Lung Cancer Diagnosed by Transbronchial Curettage

Tomoyasu Uno¹, Hirofumi Mochizuki¹, Tsuneto Okada¹, Hirohisa Yoshizawa², Eiichi Suzuki³, Fumitake Gejyo^2
1Department of Respiratory Medicine, Tsuruoka City Shounai Hospital, Japan, ²Division of Respiratory Medicine, Niigata University Graduate School of Medicine and Dental Sciences, Japan, ³Department of Internal Medicine, Niigata University Hospital, Japan

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Background. Elevated serum amylase associated with lung cancer is a rare phenomenon. Case. A 76-year-old man was admitted to our hospital complaining of abdominal and back pain. Chest X-ray film showed abnormal shadow in bilateral lung fields and laboratory data revealed elevated level of serum amylase. Neither the pancreas nor the salivary gland had any clinical involvement. Cytology by transbronchial curettage revealed adenocarcinoma, and the cancer cells stained positively for salivary amylase immunohistochemically. Chemotherapy was ineffective, he died three months after diagnosis. Postmortem examination revealed moderately differentiated adenocarcinoma with partial papillary and tubular structures. Positive immunostaining for salivary amylase in cytoplasm of the tumor cells was reconfirmed. Conclusion. Amylase-producing lung cancer should be considered as a differential diagnosis in cases of elevated level of serum amylase.
key words: Amylase-producing lung cancer, Adenocarcinoma, Salivary type, Transbronchial curettage, Autopsy

Received: May 2, 2003
Accepted: June 20, 2003

JJLC 43 (6): 715-719, 2003