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Vol.44 No.1 contents | Japanese/English |
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- Case Report -
A Case of Amylase-producing Small Cell Lung Cancer
Seigo Minami1, Satoru Yamamoto2, Shinji Atagi1, Mayumi Suzuki1, Mitsumasa Ogawara1, Masaaki Kawahara1Department of 1Respiratory Medicine, 2Pathology, National Kinki Central Hospital for Chest Diseases, Japan
Background. The most common histology of amylase-producing lung cancer is adenocarcinoma, on the other hand, small cell carcinoma is very rare. We report a case of amylase-producing small cell lung cancer. Case. A 62-year-old man with small cell lung cancer had been treated since February 2001 with concurrent chemoradiotherapy consisting of one course of cisplatin plus etoposide, followed by three courses of cisplatin plus irinotecan. A complete response was obtained after treatment and then prophylactic cerebral irradiation was performed in May 2001. Recurrence appeared in the form of brain and right adrenal metastasis. The resection of brain metastasis, followed by whole brain irradiation, was performed in November 2002. Thereafter, amrubicin hydrochloride was administered as second line chemotherapy. Laboratory data before chemotherapy showed marked elevation of amylase activity both in serum and urine. The amylase isozyme pattern was identified as salivary type amylase. Four courses of chemotherapy successfully led to remarkable reduction of the right adrenal gland metastasis and decrease in both of ProGRP value and serum amylase level. Transbronchial lung biopsy specimen stained positively for anti-alpha amylase antibody, which established the diagnosis of amylase-producing cancer immunohistochemically. Conclusion. A rare case of amylase-producing small cell lung cancer was reported, which was confirmed immunohistochemically.
key words: Small cell carcinoma, Amylase-producing lung cancer
Received: October 2, 2003
Accepted: December 1, 2003
JJLC 44 (1): 37-41, 2004
