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Vol.44 No.3 contents | Japanese/English |
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- Case Report -
A Case of Drug-induced Pneumonia Caused by Health Food and Suspected by the Histologic Examination of the Resected Lung for Lung Cancer
Keisei Chin1, Katsuhiko Aoyama1, Hidekazu Matsushima2, Katsumi Murai1, Yoshinori Kawabata3, Eishin Hoshi1Department of 1Chest Surgery, 2Respiratory Medicine, 3Pathology, Saitama Cardiovascular and Respiratory Center, Japan
Background. Careful examination of resected lung for lung cancer is important not only to know histological typing, degree of malignancy, and degree of progression of lung cancer but also to understand the background lung like coexisting idiopathic pulmonary fibrosis. We experienced drug-induced pneumonia which was found and finally suspected by the histological examination of the background lung lesion. Case. A 72-year-old man was diagnosed to have primary lung cancer cT1N0M0 stage IA, and he underwent right middle lobectomy. He complained of dyspnea on the 4th postoperative day. New shadows appeared in the right lower lung field on chest X-rays, and antibiotics were given but pulmonary shadows rapidly extended. Chest CT showed ground-glass opacities in both lungs. The histologic examination of resected lung tissue revealed the presence of acute eosinophilic pneumonia, and broncho-alveolar lavage fluid showed the increase of eosinophils. We suspected acute eosinophilic pneumonia as the cause of pulmonary shadows. By careful history taking, he admitted that he had taken health food including Agaricus and phellinus linteus before admission. The symptoms and chest X-ray findings improved only on the cessasion of the health food. Therefore, we diagnosed drug-induced pneumonia. Conclusion. We could diagnose drug-induced pneumonia partly by the histological examination of the background change of resected lung. There are a few reported cases of drug-induced pneumonia by health food such as Agaricus, and we must be careful from now on.
key words: Drug-induced pneumonia, Acute eosinophilic pneumonia, Agaricus, Resected lung cancer specimen, Health food
Received: January 22, 2004
Accepted: April 5, 2004
JJLC 44 (3): 167-171, 2004
