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Vol.44 No.6 contents

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- Case Report -

A Case of Lung Adenocarcinoma With Seborrheic Keratoses

Akihiro Tsujita¹, Masashi Bando¹, Akira Kobayashi¹, Shoji Ohno¹, Yukihiko Sugiyama^1
1Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, Japan

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Background. Leser-Trélat sign is characterized by the sudden appearance and rapid increase in the number and size of seborrheic keratoses. This is a skin change associated with internal malignancies. Case. Seborrheic keratoses increased rapidly on the skin of a 67-year-old woman, 4 months before lung cancer was detected. Recognizing the skin lesions as Leser-Trélat sign, we performed transbronchial lung biopsy from left B³b, which yielded a diagnosis of adenocarcinoma. Left upper lobectomy was performed. The resected specimen revealed bronchioloalveolar carcinoma. Conclusion.. Patients with seborrheic keratoses are often encountered. Careful observation of seborrheic keratoses is one of the ways to detect malignancy in its earlier stage.
key words: Leser-Trélat syndrome, Seborrheic keratoses, Lung adenocarcinoma, Bronchioloalveolar carcinoma

Received: January 6, 2004
Accepted: July 22, 2004

JJLC 44 (6): 695-700, 2004