 |
Vol.45 No.2 contents | Japanese/English |
 | Full Text of PDF (164K) Article in Japanese |
- Original Article -
Pathological Study of Usual Interstitial Pneumonia in Patients With Lung Cancer Resection: With Special Reference to Its Relationship to Subsequent Acute Exacerbation
Yoshinori Kawabata1, Katuhiko Aoyama2, Eishin Hoshi2, Mikio Ubukata3, Noboru Takayanagi3, Yutaka Sugita31Division of Pathology, Department of 2Thoracic Surgery, 3Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan
Objective. To determine the pathologic characteristics of usual interstitial pneumonia (UIP) lesions in resected cases of lung cancer with postoperative acute exacerbation. Materials and Methods. Subjects were 900 patients (673 male, 227 female, mean age 66 years) who underwent at least a lobectomy due to lung cancer during the past 15 years. UIP lesions were classified as diffuse, focal and microscopic based on their extent, and then subtyped according to macroscopic characteristics. Results. UIP lesions were noted in 211 cases (189 male, 22 female, mean age 70 years, incidence rate 23.4%) and acute worsening suspected to be acute exacerbation related to lung resection was noted in 12 cases (5.7%). Among 47 patients with diffuse UIP lesions, 5 (10.6%) showed acute worsening; among 100 patients with focal lesions 6 (6.0%) showed worsening; and among 64 patients with microscopic lesions 1 (1.6%) showed worsening. According to subtype, 9 of 72 (12.5%) with the thick-walled honeycombing type showed acute worsening and 2 of 68 patients (2.9%) with the thin-walled honeycombing type showed acute worsening, with a significant difference (P<0.05). Conclusion. Our results showed a high incidence of UIP lesions among lung cancer cases, that even tiny UIP lesions could become the cause for acute exacerbation, and that there is a UIP subtype susceptible to acute exacerbation.
key words: Idiopathic pulmonary fibrosis, Sub-clinical stage, Acute exacerbation, Usual interstitial pneumonia
Received: November 11, 2004
Accepted: February 21, 2005
JJLC 45 (2): 115-121, 2005
