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Vol.46 No.2 contents | Japanese/English |
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- Case Report -
A Case of Lung Cancer Associated with Idiopathic Thrombocytopenic Purpura
Kazutoshi Isobe1, Hidetomi Ryo2, Keishi Sugino1, Kazuhiko Natori3, Kazuhiro Kimura1, Yasuhiro Kuraishi31Department of Respiratory Medicine, 3Division of Hematology and Oncology, Department of Medicine, Toho University Omori Medical Center, Japan, 2Oi Central Hospital, Japan
Background. Idiopathic thrombocytopenic purpura is a complication occurring rarely in patients with malignant tumors. Case. Stage IIIB squamous cell carcinoma of the lung was diagnosed in the left upper lobe of a 60-year-old man. He received three courses of chemotherapy (carboplatin and docetaxel) with concurrent thoracic radiation therapy. However, 28 days after the third course of chemotherapy, his platelet count decreased to 3,000/μ l and he suffered nasal hemorrhage. Simultaneously, multiple metastastic lesions was recognized is the brain and both lungs. In addition, based on the increase of PA-IgG level and findings of bone marrow paracentesis idiopathic thrombocytopenic purpura (ITP) was diagnosed. Although, he was given corticosteroids for the treatment of ITP, the platelet count did not increased. He died following a decline in physical condition. Conclusion. We report a case of lung cancer associated with ITP after concurrent chemoradiotherapy. This is considered to occur due to paraneoplastic syndrome because ITP appeared at the same time as tumor recurrence.
key words: Lung cancer, Idiopathic thrombocytopenic purpura, Paraneoplastic syndrome
Received: October 6, 2005
Accepted: March 7, 2006
JJLC 46 (2): 155-159, 2006
