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- Original Article -

Clinical Analysis of Lung Cancer Complicated by Pulmonary Tuberculosis

Keishi Sugino^1,2, Sakae Homma^1,2, Atsushi Miyamoto¹, Hisashi Takaya¹, Susumu Sakamoto¹, Masateru Kawabata¹, Kazuma Kishi¹, Eiyasu Tsuboi¹, Kunihiko Yoshimura^1
1Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital, Japan, ²Department of Respiratory Medicine, Toho University School of Medicine, Japan

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Objective. The aim of this study was to assess the characteristic clinical features of lung cancer associated with pulmonary tuberculosis. Patients and Methods. Among 1,028 patients with pulmonary tuberculosis admitted in our hospital between 1985 and 2005, 17 (15 men, 2 women; mean age 73±8) were diagnosed as having lung cancer. Patient characteristics, clinical features, radiographic images, treatment and prognosis were evaluated retrospectively. Results. Patients were classified into 2 groups: group A (n=5), lung cancer complicated by active tuberculosis, and group B (n=12), lung cancer with tuberculosis sequelae. All patients in group A and 8 patients (33%) in group B had either stage III or IV lung cancer, whereas 4 patients in group B had stage I lung cancer. Coexistence of lung cancer and pulmonary tuberculosis in the same segment or lobe was seen in 80% (n=4) or 60% (n=3) of group A cases, respectively, and in 67% (n=8) or 8% (n=1) respectively, in group B. Mean survival in group A and group B was 9.2 months and 26.8 months, respectively. Conclusions. More attention should be paid to the possibility of development of lung cancer in individuals with a history of pulmonary tuberculosis or who have had tuberculosis sequelae revealed by chest radiography. Also, the possible coexistence of lung cancer must be carefully examined in patients with active pulmonary tuberculosis.
key words: Pulmonary tuberculosis, Sequelae of pulmonary tuberculosis, Primary lung cancer

Received: July 19, 2006
Accepted: January 12, 2007

JJLC 47 (2): 97-103, 2007