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Vol.47 No.3 contents | Japanese/English |
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- Case Report -
A Resected Case of Pulmonary Large Cell Neuroendocrine Carcinoma with Brain Metastasis, Which Occurred During Treatment of Breast Cancer
Naoki Hino1, Masaru Tsuyuguchi1, Yasushi Nakagawa11Department of Surgery, Tokushima Municipal Hospital, Japan
Background. In 1999, pulmonary large cell neuroendocrine carcinoma (LCNEC) was categorized as new histologic type by the World Health Organization (WHO) classification. It is known that the prognosis of LCNEC is worse than that of the other non-small cell lung carcinomas. We report a resected case of LCNEC with metastasis to the brain, in which the patient is alive for 2 years after the surgery with no recurrence. Case. A 39-year-old woman underwent an operation for breast cancer in December 2001. In May 2003 we recognized a small tumor in the right upper lung. Although hormone therapy was given since it was thought to be a hematogenous metastasis from the breast cancer, it grew gradually, and a cerebellar tumor was found in October 2004. It was removed surgically and diagnosed as a metastatic brain tumor from LCNEC. We performed right upper lobectomy for primary lesion in January 2005. The postoperative stage was IV, pT4N0M1, and chemotherapy was performed postoperatively. For 2 years since this operation, she has been alive without any recurrence and has returned to work. Conclusion. We encountered a rare case of LCNEC in which the primary lesion and brain metastasis were removed surgically. If appropriate choice of case is done, operation may prolong survival time.
key words: Large cell neuroendocrine carcinoma (LCNEC), Brain metastasis, Resected case
Received: February 5, 2007
Accepted: March 23, 2007
JJLC 47 (3): 269-272, 2007
