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Vol.47 No.7 contents | Japanese/English |
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- Case Report -
A Case of Primary Signet-ring Cell Carcinoma of the Lung Accompanied by Empyema
Hitoshi Suzuki1, Ichirou Kawamura2, Tadasuke Ikenouchi2, Toru Hara2, Toshiya Tokui31Department of Thoracic Surgery, 2Department of Respiratory Medicine, Anjo Kosei Hospital, Japan, 3Department of Thoracic Surgery, Yamada Red Cross Hospital, Japan
Background. Signet-ring cell carcinoma (SRCC) is common in the stomach, but it is rare in the lung. Case. A 74-year-old man was admitted to our hospital with continued high fever and massive pleural effusion. CT scan showed massive right pleural effusion and a nodular lesion in the right upper lobe. The CT-guided lung biopsy specimen yielded a diagnosis of adenocarcinoma. Right upper lobectomy with hilar and mediastinal lymph node dissection was performed. Histopathological examination demonstrated signet-ring cell carcinoma components in 80% of the specimen. The tumor cells were immunohistochemically positive for TTF-1 (thyroid transcription factor-1), SP-A (surfactant apoprotein A) and CK7 (cytokeratin-7), but not for CK20 (cytokeratin-20). The pathological stage was IIIA (T1N2M0). There was no evidence of any other primary or metastatic site. Conclusion. Signet-ring cell carcinoma is generally found in digestive organs and is very rare in the lung, but we should keep in mind that primary signet-ring cell carcinoma can originate in the lung.
key words: Signet-ring cell carcinoma (SRCC), Primary lung carcinoma, Empyema, Thyroid transcription factor-1 (TTF-1), Cytokeratin-7 (CK7)
Received: June 20, 2007
Accepted: October 9, 2007
JJLC 47 (7): 883-886, 2007
