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Vol.47 No.7 contents | Japanese/English |
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- Case Report -
A Case of Malignant Pleural Mesothelioma with Differentiation to Osteosarcoma
Kousuke Hamai1, Hiromi Egawa1,2, Aya Sakaguchi1, Mayumi Kaneko21Department of Internal Medicine, 2Department of Pathology, Hiroshima City Asa Hospital, Japan
Background. Malignant pleural mesothelioma is classified into epithelioid type, sarcomatoid type and biphasic type histologically, and a case showing differentiation to bone is rare. Case. A 78-year-old woman presented with back pain and dyspnea. We diagnosed her condition as malignant pleural mesothelioma based on the findings of chest CT and cytology of pleural effusion. Bone scintigram on admission showed accumulation of RI as a site, corresponding to that of the tumor. We provided a symptomatic treatment in consideration of systemic state of the patient, but she died about 2 months later. At autopsy we established a diagnosis of malignant pleural mesothelioma of the sarcomatoid type accompanied by differentiation to osteosarcoma. Only 6 cases of malignant pleural mesothelioma with differentiation to bone tissue have been reported in Japan, but there are extremely few cases of differentiation to osteosarcoma. This case may suggest the multipotentiality of mesothelial cell as the mechanism of differentiation to osteosarcoma. The possibility of asbestos exposure was not clear in this case. Conclusion. We reported one autopsy case of malignant pleural mesothelioma with differentiated to osteosarcoma.
key words: Malignant pleural mesothelioma, Bone scintigram, Osteosarcoma
Received: March 29, 2007
Accepted: October 19, 2007
JJLC 47 (7): 897-902, 2007
