 |
Vol.47 No.7 contents | Japanese/English |
 | Full Text of PDF (561K) Article in Japanese |
- The 21st Lung Cancer Workshop -
Histogenesis and Biology of Adenocarcinoma of the Lung
Masayuki Noguchi11University of Tsukuba Graduate School of Comprehensive Human Sciences, Japan
Adenocarcinomas developed in peripheral lung generally progress to invasive carcinoma through bronchioloalveolar carcinoma (BAC). When classifying small sized lung adenocarcinomas that include a BAC component pathologically, it is reasonable to divide them into two groups: replacement type and non-replacement type. Although the latter is invasive regardless of its size, the former group that includes a BAC component, particularly pure-BAC which is in situ carcinoma, shows an extremely favorable prognosis, although the prognosis becomes worse as fibroblast proliferation progresses. Many studies have examined the relationship between fibrosis or fibroblast proliferation and outcome, and morphologically, ratio between areas of fibrosis and fibroblast proliferation is known to affect outcome. Molecular biological studies have shown that BAC has a characteristically high rate of Bax inhibitor-1 expression and frequent mutation of epidermal growth factor receptor (EGFR) gene, but BAC does not show hypermethylation of p16 gene. These differences between BAC and non-BAC indicate that the character of BAC clearly differs from that of invasive adenocarcinoma (non-BAC).
key words: Lung adenocarcinoma, Noguchi's classification, Prognosis, OCIAD2
JJLC 47 (7): 921-925, 2007
