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Vol.49 No.1 contents | Japanese/English |
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- Case Report -
A Case of Pulmonary Lymphoepithelioma-like Carcinoma with Epstein-Barr Virus Infection
Noriyuki Matsutani1, Yuichi Ozeki1, Hideyuki Shimazaki2, Shinsuke Aida2, Sadayuki Hiroi31Department of Surgery II, 2Department of Laboratory Medicine, 3Department of Pathology, National Defense Medical College, Japan
Background. Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare tumor and development of the disease is thought to be involved with Epstein-Barr virus (EBV) infection. The majority of LELC is reported mostly in Asia, however, it is rarely seen in Japan. Case. A 73-year-old man presented with cold-like symptom and an abnormal shadow was found in the left lung. A computed tomography scan of the chest revealed an ill-defined round mass 2.5 cm in diameter, in left S8 or S9. Lung cancer was suspected from the result of preoperative bronchial lavage. Therefore, left lower lobectomy with partial removal of a lymph node (ND2a) was performed. Pathologically, the tumor was composed of nests of large malignant cells with marked lymphocyte and plasma cell infiltration. The histopathological diagnosis was LELC, pT1N0M0 (stage IA). The EBV antibody titer in serum obtained preoperatively was positive and quantitative analysis of EBV by real-time PCR was also positive. Conclusion. Involvement of EBV infection in this case of LELC was confirmed using ISH method and real-time PCR. A review of the literature showed that only 9 cases of LELC, including the present case, have been reported so far in Japan and 7 of them were positive for EBV infection.
key words: Lymphoepithelioma-like carcinoma, Epstein-Barr virus, Real-time PCR, ISH method
Received: April 30, 2008
Accepted: October 8, 2008
JJLC 49 (1): 25-29, 2009
