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Vol.49 No.6 contents | Japanese/English |
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- The 23rd Lung Cancer Workshop -
Understanding of Molecular Aspects of Lung Carcinogenesis and New Therapeutic Target Discovery Based on Comprehensive Gene and Protein-expression Profiles
Yataro Daigo1, Yusuke Nakamura11Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan
Progress in omics science including genomics and proteomics has enabled us to obtain comprehensive gene- and protein-expression profiles of cancers. We performed gene expression profile analysis of 101 archived lung cancers using an originally developed cDNA microarray system. Through a subsequent systematic approach using a tissue microarray containing 900 archived lung cancers, coupled with siRNA experiments, and high throughput enzyme-linked immunosorbent assay techniques covering serum samples from 500 lung cancer patients, as well as serum glycoproteomics that allows the high-throughput recognition of cancer-associated aberrant glycosylations, we have identified a set of oncoantigens and elucidated new cancer pathways that can be regarded as potential targets for the development of cancer biomarkers as well as being useful in the development of small molecule drugs, antibody drugs, peptide/siRNA-based drugs, and cancer vaccines. We here describe our effort to clarify the molecular mechanisms of lung carcinogenesis and to develop new diagnostic and therapeutic techniques based on genome-wide gene/protein expression profiles.
key words: Lung cancer, Omics, Therapeutic target, Biomarkers, Personalized medicine
JJLC 49 (6): 917-927, 2009
