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Vol.50 No.7 contents | Japanese/English |
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- Case Report -
A Case of Primary Pleural Synovial Sarcoma
Johsuke Hara1, Kouichi Nishi1, Shingo Nishikawa1, Yoshio Tsunezuka2, Kazuo Kasahara3, Masaki Fujimura31Department of Respiratory Medicine, 2Department of Respiratory Surgery, Ishikawa Prefectural Central Hospital, Japan, 3Department of Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, Japan
Background. Primary synovial sarcoma of the pleura and lung is extremely rare. Case. A 35-year-old man was admitted to our hospital because of an abnormal opacity in the right lung. A malignant intrathoracic tumor was suspected and a video-assisted thoracoscopic biopsy was performed. The right thoracic cavity was occupied by a fragile tumor. Histologically, the tumor showed dense proliferation of spindle cells with high rate of mitosis. Immunohistochemical examination was performed, but no definitive diagnosis was obtained. Progression of the tumor was very rapid and he died of respiratory failure 2 months after first presentation. On autopsy, the right lung was compressed and collapsed by the tumor. An SYT-SSX2 fusion gene transcript was detected by reverse transcription polymerase chain reaction (RT-PCR) and direct sequencing using RNA extracted from resected tissue specimens. There was no evidence of tumor except in the pleura. The final diagnosis was primary pleural synovial sarcoma. Conclusion. We report an extremely rare case of primary pleural synovial sarcoma.
key words: Pleural synovial sarcoma, SYT-SSX2 fusion gene
Received: May 8, 2010
Accepted: September 22, 2010
JJLC 50 (7): 906-911, 2010
