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Vol.50 No.7 contents | Japanese/English |
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- Case Report -
Therapy-related Leukemia as a Result of Long-term Chemotherapy for Non-small Cell Lung Cancer
Kazunori Shimizu1, Hidekazu Suzuki1, Tomonori Hirashima1, Motohiro Tamiya1, Yuka Matsuura1, Masashi Kobayashi11Department of Thoracic Malignancy, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Japan
Background. Recent advances in chemotherapy have prolonged the survival of lung cancer patients. However, there have been reports of patients who suffer therapy-related leukemia after chemotherapy. Case. A 64-year-old woman was given a diagnosis of adenocarcinoma (T4N0M0 stage IIIB) in 2004, and received chemotherapy with cisplatin and other drugs from 2004 to 2009, and radiotherapy for brain metastasis in 2008. In January 2009, she was admitted to our hospital with low-grade fever, fatigue, and prolonged neutropenia. A peripheral blood smear revealed a predominance of circulating myeloblasts. Examination of the bone marrow aspirate confirmed acute myelogenous leukemia. We think that therapy-related leukemia developed because of long-term chemotherapy and radiotherapy. Conclusion. Therapy-related leukemia can develop in lung cancer patients who undergo long-term therapy.
key words: Lung cancer, Chemotherapy, Therapy-related leukemia
Received: March 29, 2010
Accepted: October 1, 2010
JJLC 50 (7): 916-920, 2010
