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Vol.51 No.4 contents | Japanese/English |
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- Case Report -
Lung Cancer Associated with Remitting Seronegative Symmetrical Synovitis with Pitting Edema-like Features
Rurika Hamanaka1,2, Shuji Murakami1, Tomoyuki Yokose3, Haruhiko Nakayama1, Kouzo Yamada1, Masayuki Iwazaki21Department of Thoracic Oncology, Kanagawa Cancer Center Hospital, Japan, 2Division of General Thoracic Surgery, Department of Surgery, Tokai University School of Medicine, Japan, 3Department of Pathology, Kanagawa Cancer Center Hospital, Japan
Background. Remitting seronegative symmetrical synovitis with pitting edema (RS3PE), a paraneoplastic syndrome, has rarely been reported to be associated with lung cancer. We report a case of a patient with RS3PE who recovered after resection of a lung tumor. Case. A 79-year-old man had pitting edema of the lower legs and dorsal areas of the feet since December 2009, and thereafter, swelling in his fingers and wrists, with heat and pain in his wrists and ankles gradually developed. An abnormal shadow was incidentally identified in the left middle lung field on a chest radiograph during a medical examination in April 2010, after which he was referred to our hospital for further evaluation. A chest computed tomography scan showed a 40×37 mm mass in the left lingular segment, which was identified as lung cancer by transbronchial biopsy. We made a diagnosis of RE3PE syndrome associated with primary lung cancer and performed a left upper lobectomy with lymph node dissection. During the postoperative course, his joint symptoms rapidly recovered, and 8 months after the operation, the patient was alive and well. Conclusion. In elderly patients with pitting edema associated with rapidly evolving synovitis, paraneoplastic arthritis should be considered.
key words: Remitting seronegative symmetrical synovitis with pitting edema (RS3PE), Vascular epithelial growth factor (VEGF), Lung cancer
Received: March 1, 2011
Accepted: May 16, 2011
JJLC 51 (4): 253-258, 2011
