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Vol.51 No.7 contents | Japanese/English |
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- Case Report -
An Autopsy Case of Pulmonary Spindle-cell Carcinoma with Metastases to the Stomach
Miki Satoh1, Osamu Wakabayashi1, Yoshikazu Araya1, Fumiaki Yoshida1, Eisei Jinushi1, Takuzou Ishidate21Department of Respiratory Medicine, 2Department of Pathology, National Hospital Organization, Hakodate Hospital, Japan
Background. Pulmonary spindle-cell carcinoma is a rare type of poorly differentiated non-small cell lung cancer which consists only of spindle cells, and gastric metastasis from lung cancer is uncommon. Case. A 65-year-old man was admitted to our hospital because of coughing and bloody sputum. Chest computed tomography revealed a large mass extending from the right lower lobe to the mediastinum. We diagnosed non-small cell lung cancer (T4N2M0: stage IIIB) based on transbronchial exfoliative cytology findings. We administered 3 courses of systemic chemotherapy consisting of cisplatin and vinorelbine. However, the tumor increased in size, which resulted in the patient experiencing difficulty in swallowing due to stricture of the esophagus. Therefore, we inserted an esophageal stent in the lower thoracic esophagus. Gastroendoscopy revealed a submucosal tumor and an ulcerative lesion in the body of the stomach. Five months after admission, the patient died of respiratory failure due to multiple lung abscesses. A pathologic examination on autopsy revealed that the tumor cells in the lung and stomach consisted only of spindle cells. Immunohistochemical staining for cytokeratin 7 and vimentin was positive in the tumor cells. Conclusion. We report herein a rare case of pulmonary spindle-cell carcinoma with metastases to the stomach. Pulmonary spindle-cell carcinoma and gastric metastasis from lung cancer are considered to have poor prognoses. Further investigation is needed to understand this disease and to establish the optimal treatment.
key words: Sarcomatoid carcinoma, Spindle-cell carcinoma, Gastric metastasis, Immunohistochemical stain
Received: January 24, 2011
Accepted: October 26, 2011
JJLC 51 (7): 814-819, 2011
