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Vol.52 No.3 contents | Japanese/English |
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- Case Report -
von Recklinghausen Disease with Pulmonary Hamartoma and Lung Cancer
Motohiro Suzuki1, Hironori Ishibashi1, Chihiro Takasaki1, Naoyuki Fujiwara1, Takumi Akashi2, Kenichi Okubo11Department of Thoracic Surgery, Graduate School of Medical and Dental Sciences, 2Department of Pathology, Tokyo Medical and Dental University, Japan
Background. von Recklinghausen disease is an autosomal-dominant hereditary disorder sometimes accompanied by carcinoma but rarely by hamartoma. Case. A 66-year-old man with von Recklinghausen disease was found to have an abnormal shadow in the right upper lung field during a routine health check. The chest computed tomography demonstrated a 69×41 mm nodule invading the chest wall in the right upper lobe and a 20-mm nodule in the right S6. Transbronchial biopsy revealed non-small cell lung cancer which was classified as cT3N0M0. Resection of the right upper lobe with chest wall and partial resection of the right S6 was performed. Postoperative histological examination revealed the tumor in S6 was a hamartoma. Although von Recklinghausen disease is a risk factor for various malignant tumors and is often accompanied with pulmonary bullae, von Recklinghausen disease with lung cancer is rare. On the other hand, pulmonary bullae and hamartoma can be associated with lung cancer. To the best of our knowledge, no case of synchronous pulmonary hamartoma and lung cancer in patients with von Recklinghausen disease has been reported. Conclusion. We report a very rare case of von Recklinghausen disease with lung cancer and pulmonary hamartoma.
key words: Pulmonary hamartoma, Lung cancer, von Recklinghausen disease
Received: December 28, 2011
Accepted: May 28, 2012
JJLC 52 (3): 320-325, 2012
