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Vol.53 No.2 contents | Japanese/English |
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- Case Report -
Two Patients with Advanced Stage III Lung Cancer Completely Resected Following Concurrent Chemoradiotherapy (S-1 and CDDP) in Whom a Pathological Complete Response (CR) Was Obtained
Kotaro Matsumoto1, Masato Katoh1, Hitoshi Ichimiya11Department of Surgery, Hamanomachi General Hospital, Japan
Background. We herein report the cases of two patients with stage III non-small-cell lung cancer (NSCLC) who were treated with preoperative concurrent chemoradiotherapy (CCRT) containing CDDP plus S-1 with concurrent radiation therapy followed by surgery. Both patients underwent curative resection with a pathological CR (complete response). Case 1. Patient 1 was a 50-year-old male with adenocarcinoma (cT4N2M0) of the left lung. Following the administration of CCRT, a partial response was achieved, and the patient underwent left upper lobectomy with pulmonary angioplasty. Case 2. Patient 2 was a 49-year-old female with squamous cell carcinoma (cT3N1M0) of the right lung. Following the administration of CCRT, a partial response was achieved, and right upper lobectomy was performed with partial resection of the 2nd, 3rd and 4th ribs and reconstruction of the chest wall using Composix mesh. Both cases were proven to be a pathological CR based on the findings of surgical specimens, and the patients are currently alive without recurrence more than one year after undergoing surgery. Conclusions. Preoperative concurrent chemoradiotherapy with CDDP plus S-1 is useful for treating locally advanced non-small-cell lung cancer.
key words: Locally advanced non-small-cell lung cancer, Concurrent chemoradiotherapy, S-1, CDDP, Pathological complete response
Received: November 12, 2012
Accepted: April 9, 2013
JJLC 53 (2): 132-137, 2013
