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Vol.55 No.3 contents | Japanese/English |
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- Case Report -
A Case Report of Hepatoid Adenocarcinoma of the Lung
Yoshinari Matsuda1, Masahiro Kitada1, Satoshi Hayashi1, Kei Ishibashi1, Shunsuke Yasuda1, Yoshinobu Ohsaki11Respiratory Center, Asahikawa Medical University, Japan
Background. Hepatoid adenocarcinoma of the lung is a α-fetoprotein-producing lung cancer and a rare disease with a hepatocellular carcinoma-like tissue form. Case. We herein report the case of a 75-year-old man with a α-fetoprotein-producing cancer diagnosed as hepatoid adenocarcinoma of the lung. The patient was referred to our hospital for an investigation of an abnormal shadow in the left lung found on CT of the chest at a group medical examination. He was subsequently diagnosed with primary lung cancer based on an investigation in the respiratory internal medicine department, at which time left lower lobectomy with mediastinal lymph node dissection was performed under thoracoscopic assistance. The histopathological morphology of the resected tumor tissue was similar to that of hepatocellular carcinoma, and the tumor was immunohistochemically positive for α-fetoprotein. Therefore, we diagnosed the α-fetoprotein-producing lung cancer as hepatoid adenocarcinoma of the lung. The patient's postoperative course was uneventful. Although the serum α-fetoprotein level immediately after the operation was abnormally high, it returned to the normal range approximately two months after the surgery. The patient is currently doing well without any signs of recurrence. Conclusions. As the prognosis of hepatoid adenocarcinoma of the lung is poor, long-term follow-up while carefully monitoring the serum α-fetoprotein levels and utilizing various imaging modalities is essential after surgery.
key words: Lung cancer, α-fetoprotein, Hepatoid adenocarcinoma
Received: March 15, 2015
Accepted: May 9, 2015
JJLC 55 (3): 161-165, 2015
