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Vol.55 No.7 contents | Japanese/English |
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- Original Article -
The Antiemetic Efficacy of Aprepitant in Patients with Advanced Non-small-cell Lung Cancer Who Are Treated with Pemetrexed and Carboplatin
Tomohide Sugiyama1, Takashi Kasai1, Yukari Kamiyama1, Kiyoshi Mori21Department of Medical Oncology, Division of Thoracic Oncology, Tochigi Cancer Center, Japan, 2Department of Thoracic Diseases, Division of Thoracic Oncology, Tsuboi Cancer Center Hospital, Japan
Objective. The aim of this study was to prove the antiemetic efficacy of aprepitant in patients treated with a combined regimen of pemetrexed and carboplatin. Methods. A phase II trial of a combined regimen of carboplatin (AUC 6) and pemetrexed (500 mg/m2) was conducted. The two drugs were administered on day 1 and every 3 weeks thereafter. Aprepitant was not administered during the first course but was given as an additional treatment from the second course to 14 patients who experienced grade ≥2 nausea in the first course, in order to investigate its antiemetic efficacy. Results. There were 11 male and 3 female patients, with a median age of 62 years. Four patients had a performance status (PS) of 0, and 10 had a PS of 1. All of the cases were of adenocarcinoma. During the first course, grade 2 and 3 nausea occurred in 12 and 2 patients; grade 0, 1, and 2 vomiting, in 7, 6, and 1 patients; and grade 1, 2, and 3 anorexia, in 6, 6, and 2 patients, respectively. All of the cases corresponded to the delayed phase. During the second course, grade 0, 1, and 2 nausea occurred in 8, 2, and 4 patients; grade 0 and 1 vomiting, in 13 and 1 patients; and grade 0, 1, and 2 anorexia, in 7, 3, and 4 patients, respectively; which indicated a significant improvement. The severity of nausea, vomiting and anorexia decreased in 11 (78.5%), 13 (92.8%); and 8 (57.1%) patients, respectively. Conclusion. Aprepitant was an effective antiemetic in patients who were treated with pemetrexed/carboplatin and could be useful in the delayed phase.
key words: Chemotherapy induced nausea and vomiting (CINV), Antiemetics, Aprepitant, Carboplatin, Pemetrexed
Received: August 27, 2015
Accepted: October 5, 2015
JJLC 55 (7): 1065-1069, 2015
