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Vol.61 No.1 contents | Japanese/English |
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- Case Report -
A Case of Small Cell Lung Cancer with Complete Remission and PR3-ANCA Improvement by Chemotherapy
Hideto Oshita1, Tatsuki Takahashi1, Misato Senoo1, Kunihiko Funaishi1, Yasuyuki Mitama1, Ken Okusaki11Department of Internal Medicine, Mihara Medical Association Hospital, Japan
Background. Antineutrophil cytoplasmic antibodies (ANCA) are highly specific for ANCA-related vasculitis and are used to assist in its diagnosis. Although ANCA may also be present in patients with malignant tumors, few studies have reported lung cancer patients with false-positive ANCA tests. Case. A 66-year-old man was admitted to our hospital with suspected refractory pneumonia and was diagnosed with small cell lung cancer by bronchoscopy. Although his serum was positive for PR3-ANCA, no findings of vasculitis were observed, suggesting the false-positive detection of PR3-ANCA. Chemotherapy was effective against his lung cancer, and a complete remission was obtained, at which point his PR3-ANCA levels became negative. There was no recurrence of lung cancer and his PR3-ANCA level remained negative. Conclusion. Although rare, lung cancer patients may show false-positive ANCA tests results and their disease status may be evaluated according to the change in their ANCA titer.
key words: Small cell lung cancer, Complete remission, Proteinase 3-antineutrophil cytoplasmic antibody (PR3-ANCA)
Received: September 4, 2020
Accepted: November 18, 2020
JJLC 61 (1): 54-58, 2021
