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Vol.62 No.4 contents | Japanese/English |
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- Original Article -
Predicting Malignancy Grade of Lung Adenocarcinoma by Preoperative Diagnostic Imaging
Mao Yoshikawa1, Hiroyuki Tao1, Hisao Mizutani11Department of Thoracic Surgery, Japanese Red Cross Society Himeji Hospital
Objectives. This study verified whether or not high-resolution computed tomography (CT) and fluorodeoxyglucose-positron emission tomography (FDG-PET)/CT are useful for predicting the tumor malignancy grade in lung adenocarcinoma. Materials and Methods. We identified 78 patients with cTis/T1 adenocarcinoma of the lung who underwent FDG-PET/CT at the same hospital and received surgery between April 2016 and February 2021. We classified them into three groups based on the 5th WHO grade classification. The relationships between the groups and clinicopathological factors, including the consolidation tumor ratio (CTR) and maximum standardized uptake value (SUVmax), were investigated. The cut-off values of the CTR and SUVmax, which predict high-grade malignant tumors, were obtained by a receiver operating characteristic (ROC) analysis, and we combined both values for the evaluation. Results. There were significant differences in the CTR and SUVmax values among the three groups. The rates of lymphovascular invasion and lymph node metastasis were higher in the high-grade group than in the low-grade group. The cut-off values for predicting high-grade malignancy were 97.6% and 3.35 for the CTR and SUVmax, respectively. When the CTR of the tumor was ≥98% and the SUVmax was >3.35, the sensitivity and specificity for the detection of high-grade lesions were 87.5% and 85.5%, respectively. Conclusion. High-grade malignant cTis/T1 lung adenocarcinoma can be detected by high-resolution CT and FGD-PET/CT.
key words: Lung cancer, Invasive adenocarcinoma, Consolidation tumor ratio: CTR, FDG-PET, SUVmax
Received: October 1, 2021
Accepted: May 2, 2022
JJLC 62 (4): 299-303, 2022
