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Vol.62 No.5 contents | Japanese/English |
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- Case Report -
A Case of Takotsubo Cardiomyopathy with Seizure due to Brain Metastasis After Curative Operation for Lung Cancer
Madoka Goto1, Yasuhisa Ichikawa1, Hideki Tsubouchi1, Yuta Kawasumi1, Koichi Fukumoto2, Mika Uchiyama1, Shoichi Mori11Department of Thoracic Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Japan, 2Department of Thoracic Surgery Graduate School of Medicine, Nagoya University, Japan
Background. Takotsubo cardiomyopathy (TCM) is characterized by Takotsubo-shaped apical akinesis and hyperkinesis in the basal segment of left ventricle, which was first described by Dote et al. in 1991. There have been many case reports on TCM associated with surgery, chemotherapy, and seizure; however, TCM associated with seizure due to brain metastasis from lung cancer is extremely rare. Case. A 72-year-old man underwent left upper lobectomy with lymph node dissection in February 20XX, (pT2aN0M0, stage IB, pleomorphic carcinoma). In September 20XX, he was referred to the emergency unit due to seizure and respiratory failure. Gadolinium-enhanced magnetic resonance imaging (MRI) of the brain showed a metastatic tumor accompanied by brain edema. Based on the Takotsubo-shaped left ventricle and low ejection fraction on echocardiography, we diagnosed him with TCM associated with brain metastasis of lung cancer. After treatment with anticonvulsant and anticoagulant drugs, his cardiac function soon improved, and he was discharged from the hospital on day 14 from emergent admission. Unfortunately, however, despite stereotactic body radiotherapy for the metastatic brain tumor, he died of cancer in October 20XX+1. Conclusion. To our knowledge, this is an extremely rare case of TCM related to physical stress from seizure due to brain metastasis of lung cancer. An immediate diagnosis and treatment are essential, as TCM is sometimes misdiagnosed as ischemic heart disease.
key words: Takotsubo cardiomyopathy, Brain metastasis, Lung cancer, Pleomorphic carcinoma, Seizure
Received: April 1, 2022
Accepted: May 16, 2022
JJLC 62 (5): 377-381, 2022
