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Vol.54 No.7 contents

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- Original Article -

A Retrospective Analysis of Combination Treatment with Chemotherapy and Accelerated Hyperfractionated Thoracic Radiotherapy for Limited-stage Small-cell Lung Cancer -Comparison of 45 Versus 54 Gy-

Kanji Matsuura¹, Tsuyoshi Katsuta¹, Shinichiro Miura², Yusuke Hata², Junya Inata², Masashi Kanehara², Yasuo Iwamoto³, Masayuki Kagemoto^1
1Department of Radiation Oncology, ²Department of Respiratory Medicine, ³Department of Medical Oncology, Hiroshima City Hospital Organization, Hiroshima City Hiroshima Citizens Hospital, Japan

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Objective. In this study, we evaluated the efficacy of accelerated hyperfractionated thoracic radiotherapy (AHF-TRT) with a high dose of 54 Gy for limited-stage small-cell lung cancer (LS-SCLC). Methods. We retrospectively assessed the results of nine patients treated with 45 Gy of AHF-TRT and 10 patients treated with 54 Gy between 2006 and 2012. The median patient age was 65 years, ranging from 50 to 72 years. There was one stage IIA patient, 12 stage IIIA patients and six stage IIIB patients. Results. The median survival time (MST) in the 45 Gy group was 23.6 months, whereas that in the 54 Gy group has not yet been reached. A comparison of the 45 and 54 Gy groups at two years showed overall survival rates of 33.3% vs. 60.0%, (p=0.3941), with progression-free survival rates of 0% vs. 60.0% (p=0.0191), in-field progression-free survival rates of 11.1% vs. 60.0% (p=0.1312) and distant metastasis-free survival rates of 11.1% vs. 60.0% (p=0.0231). No grade 3+ non-hematological adverse effects were observed. Conclusions. The outcomes obtained in this study suggest that dose escalation to 54 Gy on AHF-TRT for LS-SCLC is a promising modality for improving treatment results, with a low incidence of severe toxicities.
key words: Limited-stage small-cell lung cancer (LS-SCLC), Accelerated hyperfractionation (AHF), Thoracic radiotherapy (TRT)

Received: August 26, 2014
Accepted: October 20, 2014

JJLC 54 (7): 930-936, 2014