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Vol.57 No.2 contents Japanese/English

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Article in Japanese

- Original Article -

The Prognostic Factors for Long-term (≥5 Years) Survival in Stage IV Non-small Cell Lung Cancer

Tatsu Matsuzaki1, Shinnosuke Ikemura1, Shotaro Chubachi1, Shingo Nakayama1, Eri Iwami1, Minako Sato1, Takahiro Nakajima1, Keisuke Eguchi2, Takeshi Terashima1
1Department of Respiratory Medicine, 2Department of Surgery, Tokyo Dental College, Ichikawa General Hospital, Japan

Objective. The aim of this retrospective study was to evaluate the prognostic factors for long-term survival (≥5 years) in patients with stage IV NSCLC. Methods. We reviewed 66 patients with stage IV NSCLC who were diagnosed at our hospital from 10/1/2002 to 9/30/2010. Results. In comparison to 58 patients who survived for <5 years, 8 patients who survived for ≥5 years were more likely to have an EGFR mutation positive, an early N status (N0, N1), and a single metastatic site. Age <75 years, an early N status (N0, N1), and the absence of liver metastasis were independent prognostic factors. Among the patients who survived for ≥5 years, the rate of EGFR-TKI use was higher, the rate of disease control in patients who were treated with both cytotoxic drugs and an EGFR-TKI was higher, and progression-free survival was longer in patients who were treated with cytotoxic drugs and an EGFR-TKI in comparison to patients who survived for <5 years. Conclusion. Our results suggest that age <75 years, an early N status (N0, N1), and the absence of liver metastasis may contribute to long-term survival in patients with stage IV NSCLC. We should take these results into consideration when deciding aggressive therapy.
key words: Long-term survivor, Non-small cell lung cancer (NSCLC), Stage IV

Received: September 14, 2016
Accepted: January 11, 2017

JJLC 57 (2): 88-95, 2017

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