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Vol.57 No.2 contents | Japanese/English |
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- Case Report -
Death due to Invasive Pneumococcal Disease During Chemotherapy for Small Cell Lung Cancer
Takehiro Yajima1, Daisuke Jingu1, Satoshi Ubukata1, Hiroshi Watanabe11Department of Respiratory Medicine, Saka General Hospital, Japan
Background. We herein report a case of unexpected death due to invasive pneumococcal disease during chemotherapy for small cell lung cancer. Case. A 65-year-old man was diagnosed with extensive-stage disease small cell lung cancer, cT1bN3M1b (OSS, HEP), cStage IV. He had received cisplatin and etoposide as first-line chemotherapy, amrubicin as second-line chemotherapy, and irinotecan as third-line chemotherapy. He developed a fever and expectorated purulent sputum on the 27th day of the second course of third-line chemotherapy and was hospitalized with right lower lobe pneumonia. Penicillin-sensitive Streptococcus pneumoniae was isolated from his sputum and blood. His respiratory condition rapidly worsened, and he was placed on a mechanical ventilator on the day of hospitalization. Despite antibiotic treatment and intensive care, he died due to acute renal failure and septic shock. He had never been given a pneumococcal vaccine. Conclusion. Patients treated with chemotherapy sometimes miss a chance to receive pneumococcal vaccination due to their tight chemotherapy schedule. Unvaccinated patients who receive chemotherapy should be vaccinated against pneumococcal disease proactively.
key words: Lung cancer, Invasive pneumococcal disease, Pneumococcal pneumonia, Pneumococcal vaccine, Chemotherapy
Received: September 24, 2016
Accepted: January 4, 2017
JJLC 57 (2): 102-106, 2017
