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Vol.57 No.4 contents | Japanese/English |
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- Original Article -
Induction Chemoradiotherapy Followed by Surgery in Stage IIIA/N2 Non-small-cell Lung Cancer: a Retrospective Study
Keiji Yamanashi1, Norihito Okumura1, Hidenao Kayawake2, Ayuko Takahashi1, Takashi Nakashima1, Tomoaki Matsuoka1, Hiroshige Yoshioka3, Satoshi Itasaka41Department of Thoracic Surgery, Kurashiki Central Hospital, Japan, 2Department of Thoracic Surgery, Kyoto University Hospital, Japan, 3Department of Respiratory Medicine, 4Department of Radiation Oncology, Kurashiki Central Hospital, Japan
Objective. The aim of this study was to investigate the outcomes of induction chemoradiotherapy followed by surgery in patients with stage IIIA/N2 non-small-cell lung cancer (NSCLC). Methods. We retrospectively analyzed 48 consecutive patients with stage IIIA/N2 NSCLC who underwent induction chemoradiotherapy followed by surgery at Kurashiki Central Hospital between January 2005 and December 2013. Results. The median age was 69 (range, 49-79) years. Thirty-eight patients were male. The diagnoses included adenocarcinoma (n=22), squamous cell carcinoma (n=17), and other types (n=9). The regimens consisted of carboplatin and paclitaxel (n=43), and other regimens (n=5) plus concurrent radiation at a dose of 30 Gy (n=20), 40 Gy (n=21), or 50 Gy (n=7). A major response was obtained in 40 patients. Grade 3/4 toxicities were reported as a result of induction chemoradiotherapy in 29 patients. The 5-year relapse-free survival and overall survival rates were 54.3% and 59.0%, respectively. Multivariate analyses revealed that the administration of carboplatin and paclitaxel in induction chemoradiotherapy was an independent prognostic factor. Conclusion. Carboplatin and paclitaxel might therefore be a promising induction chemoradiotherapy regimen for stage IIIA/N2 NSCLC.
key words: Stage IIIA/N2 non-small-cell lung cancer, Induction chemoradiotherapy, Surgery, Carboplatin, Paclitaxel
Received: December 28, 2016
Accepted: April 30, 2017
JJLC 57 (4): 272-277, 2017
