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Vol.57 No.6 contents | Japanese/English |
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- Case Report -
A Case of Thymic Large Cell Neuroendocrine Carcinoma with Pulmonary Large Cell Neuroendocrine Carcinoma at the Same Time
Naohiro Yamamoto1, Kazuhiro Ueda1, Junichi Murakami1, Toshiki Tanaka1, Kumiko Yoshida1, Kimikazu Hamano11Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Japan
Background. Large cell neuroendocrine carcinoma (LCNEC) is a relatively rare histological type. Little has been reported on synchronous multifocal LCNECs. Case. A 75-year-old man complained of intractable cough for 6 months. Chest computed tomography showed a mass measuring 75 mm in the anterior mediastinum and a nodule measuring 11 mm in the left lower lobe. A transthoracic needle biopsy suggested the mediastinal tumor to be neuroendocrine carcinoma. The mediastinal tumor invaded the left brachiocephalic vein, internal thoracic artery and vein, phrenic nerve and the left upper lobe but was completely resected through median sternotomy. Wedge resection of the left lower lobe was performed. The pathological findings revealed that the cells of both tumors were accompanied by scanty cytoplasm, irregular large nucleoli, vesicular chromatin, and a high mitotic rate, forming neuroendocrine architecture. Immunohistochemical staining showed both tumors to be positive for chromogranin A, synaptophysin, CD56 and CK (MNF116). However, the tumor cell size, nucleus shape, cell arrangement and TTF-1 expression were different between the mediastinal and lung tumors. These tumors were therefore suggested to be synchronous double LCNECs of the thymus and the lung. Conclusion. We herein presented a rare case of synchronous double LCNECs of the thymus and lung that were completely resected at the same time.
key words: Thymic large cell neuroendocrine carcinoma, Pulmonary large cell neuroendocrine carcinoma, Synchronous double cancer
Received: April 3, 2017
Accepted: August 1, 2017
JJLC 57 (6): 781-786, 2017
