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Vol.57 No.7 contents | Japanese/English |
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- Case Report -
A Case of Pleomorphic Carcinoma of the Lung with Gingival and Gastroduodenal Metastases That Resulted in Small-intestinal Perforation
Taro Yoneda1, Hideharu Kimura1, Hayato Koba1, Shingo Nishikawa1, Takashi Sone1, Kazuo Kasahara11Department of Respiratory Medicine, Kanazawa University Hospital, Japan
Background. The prognosis of pleomorphic carcinoma of the lung is poor. Case. A 59-year-old man was referred to our hospital and presented with back pain and hemosputum. After an evaluation, he was diagnosed with pleomorphic carcinoma of the lung (cT2bN2M1b stage IV [ADR]). He was systemically administered three cycles of carboplatin plus paclitaxel, but metastases in the right adrenal gland and liver worsened. Severe anemia was also confirmed. Gastric and duodenal metastases of pleomorphic carcinoma were confirmed using an upper and lower gastrointestinal endoscope. Swollen lower gingiva emerged at the same time and was diagnosed as metastasis of pleomorphic carcinoma as well. The patient was administered two cycles of nivolumab as a second-line treatment; nonetheless, the liver metastases progressed. One week after the last treatment, small-intestinal perforation occurred due to small-intestinal metastases, which was thought to be causally related to the severe anemia. Conclusion. We observed a rare case of pleomorphic carcinoma of the lung that developed into small-intestinal perforation with gastroduodenal, hepatic, and gingival metastases. In this case, nivolumab administration was ineffective.
key words: Pleomorphic carcinoma of the lung, Gastrointestinal metastases, Small intestine metastases, Gingival metastases, Immune checkpoint inhibitors
Received: July 19, 2017
Accepted: October 10, 2017
JJLC 57 (7): 860-865, 2017
