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Vol.58 No.1 contents | Japanese/English |
 | Full Text of PDF (270K) Article in Japanese |
- Original Article -
A Review of Resected Pleomorphic Carcinoma Cases
Yuki Matsui1, Yasushi Sakamaki1, Takashi Hiroshima1, Ryo Tanaka1, Kiyoshi Komuta2, Masahiko Tsujimoto3, Hironao Yasuoka31Department of Chest Surgery, 2Department of Respiratory Medicine, 3Department of Pathological Examination, Osaka Police Hospital, Japan
Background. Primary lung pleomorphic carcinoma is a rare entity showing a poor prognosis. We investigated the clinicopathological characteristics of lung pleomorphic carcinoma in our surgical cases. Subjects and Methods. A total of 14 patients who underwent surgery with curative intent for lung pleomorphic carcinoma at our institution between January 2005 and December 2015 were reviewed. Results. The study included 14 patients (12 men and 2 women) with the mean age of 69.5 years. Lobectomy was performed on 13 patients and segmentectomy on 1. The pathological diagnosis was stage I in 4 patients, stage II in 6, and stage III or higher in 4. Tumor recurrence was found in 8 patients who all died of recurrent cancer. The 5-year overall survival rate was 21.0% for all patients. An immunohistochemical study of the resected tumor revealed the expression of programmed cell-death ligand 1 (PD-L1) in 12 patients, 5 of whom had tumors strongly expressing PD-L1. The further accumulation of cases will hopefully help clarify the details of primary lung pleomorphic carcinoma.
key words: Pleomorphic carcinoma, Lung cancer, Surgical outcome, Surgical resection, PD-L1
Received: August 18, 2017
Accepted: December 15, 2017
JJLC 58 (1): 24-28, 2018
