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Vol.58 No.2 contents | Japanese/English |
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- Original Article -
Usefulness of EBUS-TBNA in the Staging of Lung Cancer in Patients with Sarcoidosis and Sarcoid Reactions
Kosuke Ichikawa1, Satoshi Watanabe1, Rie Kondo1, Satoshi Shoji1, Nobumasa Aoki1, Yasuyoshi Ohshima1, Takuro Sakagami1, Hiroshi Moro1, Toshiyuki Koya1, Toshiaki Kikuchi11Department of Respiratory Medicine and Infectious Diseases, Niigata University Medical and Dental Hospital, Japan
Objective. Sarcoidosis is a systemic disease that causes the formation of noncaseating epithelioid granuloma in various organs and which often exhibits hilar and mediastinal lymphadenopathy. Among lung cancer patients with sarcoidosis or sarcoid reactions, it is difficult to evaluate the lymph node status and stage by CT and FDG-PET/CT scans. In this study, we examined the usefulness of EBUS-TBNA in the staging of the lung cancer in patients with sarcoidosis or sarcoid reactions. Materials and Methods. We evaluated the effectiveness of EBUS-TBNA in lung cancer patients with sarcoidosis or sarcoid reactions from January 2009 to December 2016. Results. We found 4 patients who were diagnosed with lung cancer accompanied by sarcoidosis and sarcoid reactions by EBUS-TBNA. All of these patients had hilar and mediastinal lymphadenopathy. EBUS-TBNA was useful for the differential diagnosis of lymph-node metastasis of lung cancer. Three of the 4 patients were diagnosed with stage I non-small cell lung cancer and surgery was performed in 2 cases. The histopathological examination of the surgical specimens confirmed that these patients had sarcoid reactions with no lymph-node metastasis. One of the 4 patients was diagnosed with stage III non-small cell lung cancer with systemic sarcoidosis. Conclusion. EBUS-TBNA seems to be useful for the evaluation of the lymph-node status of lung cancer patients with sarcoidosis and sarcoid reactions.
key words: Sarcoidosis, Sarcoid reaction, Lung cancer, Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)
Received: August 25, 2017
Accepted: January 22, 2018
JJLC 58 (2): 88-92, 2018
