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Vol.58 No.2 contents | Japanese/English |
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- Case Report -
A Surgical Case of Minimally Invasive Adenocarcinoma Associated with Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE) Syndrome
Katsuyuki Suzuki1, Satoshi Shiono1, Kazuki Hayasaka1, Kei Yarimizu1, Makoto Endoh1, Naoki Yanagawa21Department of Thoracic Surgery, 2Department of Pathology, Yamagata Prefectural Central Hospital, Japan
Background. Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is a paraneoplastic syndrome that causes symmetrical synovitis with pitting edema at the periphery of the arms and legs. Although 10-40% of cases of RS3PE syndrome are associated with malignant tumors, few lung cancer-associated cases have been reported. Case. At his annual health check-up, a 67-year-old man was evaluated for an abnormal chest X-ray shadow. Computed tomography revealed a lung nodule of 0.9 cm (consolidation size: 0.3 cm) in the right S2b. After a one-year observation period, the nodule was found to have grown to 1.1 cm (consolidation size: 0.7 cm) in size; thus, we decided to perform surgical resection. In the two months before surgery, the patient had suffered from pitting edema of the bilateral legs. A detailed examination was performed; however, the cause of edema could not be identified. We performed right S2 segmentectomy with hilar lymph node dissection and diagnosed minimally invasive adenocarcinoma (pT1miN0M0-stage IA1). His edema rapidly improved, and a follow-up examination at one year after surgery revealed no signs of recurrence of lung cancer or edema. We suspected that the RS3PE syndrome was associated with the patient's lung cancer. Conclusion. When evaluating lung cancer patients who develop symmetrical synovitis with pitting edema, we should consider the possibility of of RS3PE syndrome.
key words: Lung cancer, RS3PE syndrome
Received: December 5, 2017
Accepted: January 15, 2018
JJLC 58 (2): 105-110, 2018
