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Vol.58 No.2 contents | Japanese/English |
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- Case Report -
A Case of Adenoid Cystic Carcinoma of the Lung That Was Effectively Treated with Pemetrexed for a Long Period After Combination Chemotherapy with Platinum Doublet and Pemetrexed
Ayano Toriyama1, Michiharu Suga1, Angyoung Kang1, Yasukiyo Nakamura1, Chihiro Watanabe2, Hideo Kita11Department of Respiratory Medicine, 2Department of Pathology, Takatsuki Red Cross Hospital, Japan
Background. The standard chemotherapy regimen for adenoid cystic carcinoma of the lung has not been established. To the best of our knowledge, no studies have shown pemetrexed to be an effective chemotherapy. Case. A 70-year-old woman presenting with chronic cough of longer than six months in duration was admitted to our hospital. After right pneumonectomy, she was diagnosed with adenoid cystic carcinoma of the lung. At 22 months after surgery, the disease recurred. After four cycles of combination chemotherapy with pemetrexed and cisplatin followed by three cycles of maintenance chemotherapy with pemetrexed, the size of the recurrent lesions was markedly decreased. The disease recurred again after a drug-free-period. Combination chemotherapy with pemetrexed and cisplatin was restarted. During the first cycle of the combination therapy, the patient exhibited a loss of appetite. For the second and third cycles, the combination therapy was changed to pemetrexed and carboplatin. Maintenance chemotherapy with pemetrexed was continued for 36 months, without disease progression. Conclusion. Combination chemotherapy consisting of a doublet regimen of platinum compounds with pemetrexed followed by maintenance monotherapy with pemetrexed may be a therapeutic option for the treatment of adenoid cystic carcinoma of the lung.
key words: Adenoid cystic carcinoma, Postoperative recurrence, Chemotherapy, Pemetrexed, Maintenance therapy
Received: October 10, 2017
Accepted: January 22, 2018
JJLC 58 (2): 111-115, 2018
