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Vol.58 No.4 contents | Japanese/English |
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- Case Report -
The Successful Use of Somatostatin Receptor Scintigraphy to Determine the Treatment Strategy for Lung Typical Carcinoid
Yosuke Kagawa1, Soichi Kitaguchi1,2, Kaori Moriwaki1, Norihito Osaki1, Takashi Yamane1, Fumihiro Sugahara11Department of Respiratory Medicine, 2Department of Oncology Medicine, Hiroshima City Asa Citizens Hospital, Japan
Background. Lung carcinoids are rare tumors accounting for 0.8-2% of lung carcinomas. Because most lung carcinoids express somatostatin receptors, somatostatin receptor scintigraphy is useful for staging. In Japan, somatostatin receptor scintigraphy using 111In-labeled pentetreotide has been used since 2016. Case. A 67-year-old man was referred to our hospital in April 20XX because a lung mass was detected on chest X-ray. Computed tomography revealed a lung mass, a liver mass, and enlarged mediastinal lymph nodes. We diagnosed him with a typical carcinoid based on a transbronchial biopsy. Immunohistochemistry showed positive reactivity for somatostatin receptor 2. Somatostatin receptor scintigraphy revealed a marked accumulation in the lung and liver masses. Accordingly, the patient was diagnosed with liver metastasis of lung carcinoid. Despite treatment with octreotide, the tumor grew in size. However, the patient achieved stable disease 11 months later, so we performed somatostatin receptor scintigraphy again. An increased number of liver masses and new bone accumulations were observed; therefore, we switched the therapy from octreotide to everolimus. After five months, the best overall response was stable disease, and he is continuing to receive everolimus. Conclusion. These observations suggest that somatostatin receptor scintigraphy may be useful for determining the optimal treatment strategy for lung typical carcinoid.
key words: Carcinoid of the lung, Somatostatin receptor scintigraphy, Metastatic liver tumor
Received: February 17, 2018
Accepted: May 24, 2018
JJLC 58 (4): 286-291, 2018
