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Vol.59 No.2 contents Japanese/English

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Article in Japanese

- Case Report -

A Case of Small Cell Lung Cancer with Anti-Transcription Intermediary Factor 1 (TIF1)-γ Antibody-positive Dermatomyositis as Paraneoplastic Syndrome

Taisuke Isono1, Naohiko Ogawa1, Mayuko Tani1, Masaru Nishitsuji1, Koichi Nishi1
1Department of Respiratory Medicine, Ishikawa Prefectural Central Hospital, Japan

Background. Dermatomyositis is associated with an increased risk of malignancy; however, dermatomyositis occurring after the onset of lung cancer is rare. Case. A 74-year-old man was diagnosed with extensive small cell lung cancer (cT4N2M1a, PLE, cStage IVA). He had been treated with cisplatin and etoposide, and had achieved a partial response. Before the fourth course of cisplatin and etoposide, an itching rash appeared on his neck and gradually expanded. He was diagnosed with dermatomyositis based on the clinical findings of heliotrope rash, Gottron's sign, V-neck sign, shawl sign, and proximal muscle weakness. A blood test for anti-TIF1-γ antibodies was positive. After treatment with oral prednisolone (30 mg/day) and high-dose intravenous gamma globulin, his symptoms improved. Conclusion. The possibility of dermatomyositis should be noted when rash and muscle weakness appear in patients with well-controlled lung cancer.
key words: Small cell lung cancer, Dermatomyositis, Anti-TIF1-γ antibody

Received: November 2, 2018
Accepted: January 25, 2019

JJLC 59 (2): 158-162, 2019

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