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Vol.59 No.3 contents | Japanese/English |
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- Case Report -
A Case of Ovarian Metastasis from ALK-rearranged Lung Adenocarcinoma in an Elderly Woman Who Resumed Menstruation due to Estradiol Production
Keita Kawakado1, Tomoki Tamura1, Tomoka Kawajiri1, Tatsuya Nishi1, Kenichiro Kudo1, Shoichi Kuyama11Department of Respiratory Medicine, Iwakuni Clinical Center, Japan
Background. Ovarian carcinoma metastasized from lung carcinoma accounts for only 3.6% of ovarian carcinoma cases, and estradiol-producing ovarian carcinomas are even less common. Case. A 70-year-old woman presented with irregular vaginal bleeding. Seven years prior to her presentation, she had been diagnosed with advanced lung adenocarcinoma and had received several chemotherapy regimens, followed by crizotinib treatment for five years since anaplastic lymphoma kinase (ALK) rearrangement was detected by fluorescence in situ hybridization (FISH). During this period, her lung carcinoma was well controlled. A serum analysis at the time of her current presentation revealed elevated levels of tumor and estradiol. Abdominal computed tomography revealed an enlarged right ovary (6 cm). Since ovarian metastasis from lung adenocarcinoma was suspected, we performed hysterectomy with bilateral salpingo-oophorectomy. The tissue pathology confirmed metastatic ovarian carcinoma from lung adenocarcinoma. After resection, her levels of serum tumor markers and estradiol were reduced, suggesting that the tumor produced estradiol and caused the resumption of menstruation. After surgery, she received alectinib and her lung adenocarcinoma remains well controlled.
key words: Lung adenocarcinoma with ALK, Metastatic ovarian carcinoma, Estradiol
Received: August 21, 2018
Accepted: March 4, 2019
JJLC 59 (3): 254-259, 2019
